Knowledge builds confidence.
Confidence empowers decisions.
Make It Make Sense (MIMS) is here to help you understand clinical trials and explore your options so you can have more informed conversations and make decisions that are right for you.
Understand
Clear, easy-to-understand information about HER2-positive early breast cancer.
Explore
Learn about clinical trials and how research is advancing treatment options.
Ask
Get questions to help you start conversations with your healthcare team.
Empower
Feel confident making informed decisions about your care and your future.
This Months Focus
This Month’s Focus
Understanding HR+/HER2-Negative Breast Cancer
HR+/HER2-negative breast cancer is a subtype of breast cancer defined by two important biomarkers: hormone receptors (HR) and HER2.
Hormone Receptor-Positive [HR+]:
HR+ breast cancer cells have receptors that can use hormones such as estrogen and progesterone to grow.
HER2-Negative [HER2- ]:
HER2-negative breast cancer cells do not have higher-than-normal levels of the HER2 protein.
What this means for you:
Knowing your breast cancer subtype gives you information you can use when talking with your healthcare team about your care and your options.
Know Your Breast Cancer Subtype:
Learn what HR+, HER2-, and other biomarker results may tell you about your breast cancer and why this information matters.
Why Are Clinical Trials Important?
Clinical trials help researchers discover new ways to:
Clinical trials are an important option for many people and may be available at different stages of breast cancer.
Treatment options may include:
Clinical Trials | Surgery | Chemotherapy (when appropriate) | HER2-targeted therapies | Radiation therapy | Ongoing follow-up care
Did You Know?
Clinical trials for HR+/HER2-negative breast cancer are studying new ways to address how cancer may continue to grow after previous treatments. Researchers are exploring new targets and treatment combinations to expand future options.
Ask Your Healthcare Team:
“Do we have the biomarker information we need for the decisions we’re making now?”
Biomarker Education:
Learning More About Your Cancer
Biomarker testing looks for characteristics of your cancer that may provide information about how it grows and behaves.
ER – Whether cancer cells have estrogen receptors
PR – Whether cancer cells have progesterone receptors
HER2 – Whether cancer cells have higher-than-normal levels of HER2
Depending on your diagnosis and treatment history, your healthcare team may discuss whether additional testing could provide useful information.
Our Promise
MIMS is designed to provide clear, unbiased educational information about clinical trials so you can have informed conversations with your healthcare team.
“Participation in a clinical trial is always your choice.”
Featured Clinical Trial Opportunities
These studies are currently enrolling individuals who may qualify. Talk with your healthcare team to determine whether participation may be right for you.
HR+/HER2- Negative Breast Cancer
EV407 Study
Phase I/Ib | NCT07604571
A clinical trial studying investigational IEV407 alone or with endocrine therapy in people with advanced HR+/HER2-negative breast cancer.
Researchers are studying safety, dosing, side effects, and early signs of treatment response.
Learn More » novartis.com/clinicaltrials/study/NCT07604571
GVV858 Study
Phase I/II | NCT07288359
A clinical trial studying investigational GVV858 alone or with endocrine therapy in people with advanced HR+/HER2-negative breast cancer and certain other advanced solid tumors.
Researchers are studying safety, suitable doses, and how participants’ cancers respond during treatment.
Learn More » novartis.com/clinicaltrials/study/NCT07288359
HER2
BC-303 (EmpowHER-303) Study
BC-208 (EmpowHER-208) Study
Talk with your healthcare team to see if a clinical trial may be right for you.
More About Clinical Trials →
Explore Trusted Resources
Start here to learn more about your cancer and clinical trial options.
Learn More About Your Cancer
Understand your diagnosis, treatment options, and what to expect.
Explore Clinical Trial Opportunities
Learn how clinical trials work and how they may help you or others.
Find Questions to Ask Your Doctor
Helpful questions to guide your next conversation.
Learn About Clinical Trial Participation
Understand the process, your rights, and what to expect.
Thank You to Our Sponsors
Make It Make Sense (MIMS) is made possible through the generous support of our sponsors, whose commitment helps expand access to trusted cancer and clinical trial education.
